Ma J, et al. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair. Cancer Cell. 2019 Mar 18;35(3):504-518.

Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. 2019 Jan 23:1-16.


*Albuquerque, CP, *Suhandynata, RT, Carlson, CR, Yuan, W-T and Zhou, H. Binding to Small Ubiquitin-like MOdifier and the nucleolar protein Csm1 regulates substrate specificity of the Ulp2 protease. J. Biol. Chem. 2018 Aug 3;293(31):12105-12119. *Joint first authors.

*Liang J, *Li BZ, Tan AP, #Kolodner RD, #Putnam CD, #Zhou H. SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements. PLoS Genet. 2018 Mar 5;14(3):e1007250. *Joint first authors. #Corresponding authors.

Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B. Identification of H3K4me1-associated proteins at mammalian enhancers. Nat Genet. 2018 Jan;50(1):73-82.



*Liang, J., *Singh, N., Carlson C.R., Albuquerque, C.P., #Corbett, K.D., and #Zhou, H. (2017) Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev. 2017 Apr 15;31(8):802-815. *Joint first authors. #Corresponding authors.

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, et al. (2017) mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell 67: 128–138.e7.



*Albuquerque, C. P., *Liang, J., Gaut, N. J., and Zhou, H. (2016) Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements. J. Biol. Chem. 291, 8825–8835. *Joint first authors.

Suhandynata RT, Wan L, Zhou H, Hollingsworth NM (2016) Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics. PLoS ONE 11: e0155931



Albuquerque, C. P., Yeung, E., Ma, S., Fu, T., Corbett, K. D., and Zhou, H. (2015) A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. PLoS ONE10, e0143810.

Liang, J., Suhandynata, R. T., and Zhou, H. (2015) Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function. J. Biol. Chem. 290, 10751–10763.

Chen X, Suhandynata RT, Sandhu R, Rockmill B, Mohibullah N, Niu H, Liang J, Lo H-C, Miller DE, Zhou H, et al. (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol 13: e1002329.

Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, et al. (2015) Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron 86: 218–232.

Sun S, Ling S-C, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, et al. (2015) ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun 6: 6171.



Suhandynata R, Liang J, Albuquerque CP, Zhou H, Hollingsworth NM (2014) A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture. G3 (Bethesda) 4: 2125–2135.

Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, et al. (2014) Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell 54: 378–391.

Farber-Katz SE, Dippold HC, Buschman MD, Peterman MC, Xing M, Noakes CJ, Tat J, Ng MM, Rahajeng J, Cowan DM, et al. (2014) DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell 156: 413–427.



Albuquerque, C. P., Wang, G., Lee, N. S., Kolodner, R. D., Putnam, C. D., and Zhou, H. (2013) Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements. PLoS Genet. 9, e1003670.

For earlier publications of Dr. Huilin Zhou: