A basic feature of SUMO protease has been found to play an unexpected and crucial role in regulating its substrate specificity, thanks to the ingenious and elegant design of nature! We are just witnesses ..., if we keep an unassuming mind!
In a wonderful collaboration with the Kolodner lab, Jason and Alex's paper describes the genetic basis of the genomic instability defect of cells lacking Mms21 SUMO E3 ligase, which points to an important role of SUMO in regulating DNA replication.
Ray has been selected as a postdoc trainee by the Growth Regulation and Oncogenesis Training Grant (NIH/NCI T32 CA009523). Of course, Ray will be using yeast as a model organism to understand the molecular basis of cancer, as the universality of fundamental mechanism has been well documented, in case you are wondering!
Best wishes for Jason and Christie in their new jobs, which means, we are looking for new passionate students to join us!
Today, we officially begin the installation of our newest tool, the Orbitrap FUSION LUMOS mass spectrometer, thanks to fundings from both NIH SIG and LICR.
Congratulations to Jason, Chris and Claudio for their collaborative study with Kevin Corbett's group in uncovering a new mechanism on the regulation of ribosomal gene silencing by protein sumoylation, a tour de force study indeed.
Our shared instrument grant has been awarded by NIH, allowing us to acquire the latest Fusion-LUMOS mass spectrometer, which is expected to be 10x faster with greatly improved sensitivity and accuracy than our current MS systems.
We plan to install it in the near future and work with our colleagues to explore its applications.
Jason has recently defended his PhD degree, of course, with a spectacular success. Job well done but more papers to be published.
I spent much of my day, away from my computer, to play with genetics and cloning. It has come to my attention that yeast is a wonderful and master "cloner". With proper designs of PCR fragments, you can make just about anything, as yeast will do it all for you, not to mention the awesome power of yeast genetics has provided considerable new insights into genome instability and cancer!